4/3/2023 0 Comments Digoxin antidote![]() ![]() 7 It reversibly inhibits the Na-K ATPase enzyme, leading to various beneficial effects. 25 Mechanism of actionĭigoxin exerts hemodynamic, electrophysiologic, and neurohormonal effects on the cardiovascular system. 25 An increased risk of fatal severe or complete heart block is present in individuals with pre-existing sinus node disease and AV block who take digoxin. ![]() Cardiac arrest as a result of ventricular fibrillation is fatal. 25ĭigoxin poses a risk of rapid ventricular response that can cause ventricular fibrillation in patients with an accessory atrioventricular (AV) pathway. 25 Digoxin has a narrow therapeutic window. 13 The relief of heart failure symptoms during digoxin therapy has been demonstrated in clinical studies by increased exercise capacity and reduced hospitalization due to heart failure and reduced heart failure-related emergency medical visits. 23 The decrease in heart rate is particularly useful in cases of atrial fibrillation, a condition characterized by a fast and irregular heartbeat. ![]() Digoxin is a positive inotropic and negative chronotropic drug 7, meaning that it increases the force of the heartbeat and decreases the heart rate. ![]()
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